BDBM135821 US10085990, Example 118::US10568888, Example 118::US8853226, 118::US9393245, 118::US9833457, 118

SMILES COc1cccc2c1ncc1c2n([C@H]2CCN(C2)S(C)(=O)=O)c(=O)n(-c2cccc(Cl)c2)c1=O

InChI Key InChIKey=QBTZSDNOQVLDBB-INIZCTEOSA-N

Data  12 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 135821   

TargetIsoform PDE4B2 of cAMP-specific 3',5'-cyclic phosphodiesterase 4B (PDE4B2)(Homo sapiens (Human))
Vtv Therapeutics

US Patent
LigandPNGBDBM135821(US10085990, Example 118 | US10568888, Example 118 ...)
Affinity DataIC50:  80nMT: 2°CAssay Description:The assay buffer was prepared by diluting 5× supplied Tween-based buffer in 1:5 in water to make 1× buffer. Add desired additive to buffe...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetIsoform PDE4B2 of cAMP-specific 3',5'-cyclic phosphodiesterase 4B (PDE4B2)(Homo sapiens (Human))
Vtv Therapeutics

US Patent
LigandPNGBDBM135821(US10085990, Example 118 | US10568888, Example 118 ...)
Affinity DataIC50:  80nMAssay Description:A TR-FRET-based phosphodiesterase assay kit from Molecular Devices was used to test whether these compounds were indeed direct inhibitors of the PDE4...More data for this Ligand-Target Pair
In DepthDetails US Patent